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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 5% by weight of the viscosity modulating agent(s)
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Moreover, microsomal metabolism studies demonstrated that Dihexa had very low phase I metabolism, with an average intrinsic clearance of 2.72 l/min/mg and a half-life of 509.4 minutes
doi: 10.1016/j.ccell.2020.06.001
