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RNR inhibition blocks ferroptosis RNR is oxidized as part of its catalytic mechanism

A.ChhoyP.XieZ.DaiL.et al (2014)

Antiepileptic drugs and hormones in children

Testosterone and progesterone, but not estradiol, stimulate muscle protein synthesis in postmenopausal women

1 In the absence of adequate GSH concentrations, numerous oxidative and nitrosative reactive intermediates persist, including superoxide, hydroxide, peroxide, and peroxynitrite radicals, which all can lead to modification of cellular macromolecules including lipid membranes (measured in vivo by F2-isoprostanes) and DNA adduct formation (measured in vivo by 8-hydroxy-2-deoxyguanosine [8-OHdG])