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Oxidative stress results in increased expression of calreticulin, Psme3, and vimentin, which regulate TGF-1-induced proliferation and epithelial-mesenchymal transition (EMT) by modulating Smad signaling 33,34
However, simply targeting MAPK-related signals has not been effective in treating cancer (93)
doi: 10.1016/S1360-1385(00)01600-9 72 FahadS.BajwaA
They actually enhance each others effectiveness
