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In a randomized, placebo-controlled study in 251 patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary angioplasty, high-dose NAC (1200 mg IV bolus before angioplasty and 1200 mg IV bolus twice daily for 48 hours following angioplasty) reduced oxidative stress [172]

Voltammetrically monitored brain ascorbate as an index of excitatory amino acid release in the unrestrained rat
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doi: 10.1016/0006-2952(61)90119-8
