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In this review we will focus on (a) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (b) importance of oxidative stress and antioxidants in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 disease, (c) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (d) new therapies that include antioxidant defenses restoration

Nutr Cln Med 3:129140 [Google Scholar] Gardner PT, McPhail DB, Duthie GG (1998) Electron spin resonance spectroscopic assessment of the antioxidant potential of teas in aqueous and organic media
Regul Toxicol Pharmacol 71:337351

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