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Finally, we discuss promising biomarkers derived from microbial, inflammatory, and erythrocyte pathways that may facilitate early diagnosis and the development of diseasemodifying therapies

(Li et al., 2014) confirmed the localization of TIGAR in mitochondria and observed that the mitochondrial localization of TIGAR increased under the conditions of I/R and OGD/R, thereby believing that TIGAR could protect mitochondrial function

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Additionally, cystine starvation induces ferroptosis in many tested cancers

Iron in cellular biochemistry Within human cells, iron is predicted to interact with 400 different proteins [6]
