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On examination, well-demarcated areas of pigmentation localized to knuckles of both hands were noticed (Figure 1)

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Research suggests these groups would benefit from B complex supplements: Men over 50 experiencing natural testosterone decline Those with restricted diets limiting B vitamin intake Individuals with conditions affecting nutrient absorption Men with chronic stress, which depletes B vitamin stores A compelling study revealed that men with the highest serum B12 levels had substantially lower chances of testosterone deficiency compared to those with the lowest levels (adjusted OR = 0.44) [13]

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