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mRNA vaccine with antigen-specific checkpoint blockade induces an enhanced immune response against established melanoma

The new study extends this concept to skin inflammation and proposes that increased FABP5 expression funnels these redox-active lipids toward cellular membranes while suppressing the expression of GPX4, the lipid peroxidationdetoxifying enzyme and key ferroptosis suppressor, thereby amplifying lipid peroxidation and promoting inflammatory cell recruitment (Fig

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Therefore, by introducing the DRP1-specific inhibitor mdivi-1, we observed that DRP1 inhibition significantly synergized with KU-57788 to suppress ATC cell viability and colony formation (Fig

For example, Tregs that reside in visceral adipose tissue (VAT) acquire a unique VAT Treg phenotype characterized by PPAR expression (151, 152)