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and hydroxyurea to reduce complications, and rarely requires Splenectomy

Duzel et al., 2017

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In individuals who are slightly overweight but still have normal thyroid function, fat accumulation is linked to lower fT4 and higher TSH levels, resulting in an increase in body weight over time [58]

The primary endpoint, consistent with most Phase I studies, is the assessment of safety and toxicity profiles, which encompasses the incidence and severity of treatment-related adverse events graded according to CTCAE v5.0