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And then, lastly, things like the diseases of frailty but also the underlying metrics that put people at risk for cardiovascular disease, dementia, and Alzheimers disease would be a physical fitness assessment with something like a VO2 max test where you can measure your aerobic fitness

EUVAS (European Vasculitis Study Group): Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial

Alatassi says

Although the precise origin of Alzheimer's disease (AD) is unknown, a variety of factors, including a drop in acetylcholine (ACh) levels, amyloid peptide (A) building, hyperphosphorylated tau-protein deposition, and an increase in oxidative stress, appear to play a role in its start and progression [4]

Actual shelf life varies by peptide sequence, and peptides containing oxidation-sensitive residues (cysteine, methionine, tryptophan) may have shorter effective shelf lives under the same conditions