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Materials and methods Ethics statement and study site The experiment was performed at the Rabbit Laboratory, Faculty of Agriculture (Saba Basha), Alexandria University, Egypt (311220.7108"N, 295528.2936"E)

N-acetyl-cysteine (NAC) is an orally bioavailable precursor to glutathione, meaning it is used to make glutathione as an end-product

Endothelial LXR is involved in maintaining BBB integrity

Moreover, several clinical studies have identified elevated levels of numerous inflammatory markers, including CRP, TNF-, IL-1RA, sTNFR1, and sTNFR2, along with elevated serum NF-B levels, in patients with DPN compared to patients with T2DM without neuropathy, suggesting that patients with DPN exhibit a more pronounced inflammatory response (9698)

Tumpey, T