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Increased ROS production leads to disturbances in the balance between oxidation and the antioxidant defense system of the body, causing oxidative stress and this has been observed in cancer cells (Trachootham et al., 2009)

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Gentamicin is an aminoglycoside antibiotic used to treat various bacterial infections

Targeting the IGF-1R signaling pathway is considered a potential breakthrough in anticancer therapy and a number of small molecule inhibitors and monoclonal antibodies targeting IGF-1R, such as BIIB-022, BMS-754807 and Teprotumumab, have been developed and evaluated in clinical trials (113115)

Primary antibodies used were against actin (Cat