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Barbaro, and G

In women, OS is implicated in various reproductive disorders, including polycystic ovary syndrome, endometriosis, and premature ovarian failure, leading to diminished oocyte quality, disrupted folliculogenesis, and poorer reproductive outcomes

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[15] Therefore, high doses of biotin (in the tens or hundreds of milligrams) are generally reserved for research settings or specific medical conditions like certain metabolic disorders or experimental therapies (e.g., very high-dose biotin has been investigated in multiple sclerosis)