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We demonstrated that the GSH synthesis inhibitor buthionine sulfoximine (BSO) synergistically enhanced L-PAM activity (inducing 24 logs of cell kill) against nine MM cell lines (also in the presence of marrow stroma or cytokines) and in seven primary MM samples (combination indices <1.0)

In addition, interactions between essential and toxic metals involve both competitive and protective mechanisms that influence metal uptake, transport, and detoxification

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This prospective, phase IV study used an integrated genomic analysis to identify markers associated with 1-month change in IGF-I (IGF-I) following initiation of recombinant human (r-h)GH therapy in treatment-nave children with GH deficiency (GHD) (n=166) or Turner syndrome (TS) (n=147)

Ferrostatin-1 significantly mitigated these effects suggesting that lipid peroxidation drives this state