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At the transcriptional level in kidney tubular epithelial cells, glutamine supplementation can downregulate proapoptotic genes (Harakiri [HRK] and BAD) and regulate cytoprotective genes (sulfiredoxin 1 [SRXN1] and heme oxygenase 1 [HMOX1])

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Based on these molecular interactions, BPC-157 may act within wider circuits that regulate tissue architecture under experimentally induced stress

Opioid Peptides Endogenous opioids are neurotransmitters and neuromodulators that have a significant impact on the nervous system, particularly on pain regulation and reward mechanisms, by modulating numerous electrical properties of neurons and, thereby, reducing their responsiveness to many stimuli [67]
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