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doi: 10.1007/978-3-031-21547-6_8

Neither of those is the same as the regulator accepting a NAM-only package in place of animal data

Hyperglycemia stimulates the proliferation of vascular smooth muscle cells and collagen synthesis, leading to fibrosis and hardening of the vascular wall, causing blood vessels to lose their elasticity, increasing vascular resistance and pressure, and inducing diabetic cardiovascular disease
When connective tissue is weak or too stretchy, it can lead to joint instability, fragile skin, and a range of physical symptoms
Patients with DPN compared with healthy volunteers showed a decrease in walking speed by 16.0% (79.0 [68.0