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Endocrine cell depletion: Pituitary ACTH cells experience reduced secretion granules and cell apoptosis due to long-term CRH stimulation

Their microarray results showed that the expression of tumor related genes CDS1, Itga 4, Myc and Itgb 1 gene were up-regulated

Aquat Toxicol 76:112 Chae YJ, Pham CH, Lee J, Bae E, Yi J, Gu MB (2009) Evaluation of the toxic impact of silver nanoparticles on Japanese medaka ( Oryzias latipes )

Another important player are the cytokines IL-1 and TNF, which promote RGC apoptosis in the glaucomatous retina (105)

This is anecdotal
