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Deletion of the insulin receptor in a mouse model showed decreased blood glucose levels in response to IGF-1 (112), whereas in vivo reduction of serum IGF-1 by 80% impaired glucose tolerance (113)

In addition, nutritional stress caused by a high fat high carbohydrate diet promotes oxidative stress, as evident by increased lipid peroxidation products, a diminished antioxidant system and decreased glutathione levels [82,83]

As a synthetic peptide, hexarelin is modeled after its natural counterpart, ghrelin

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Bioinformatics (2002) 18:2078.10.1093/bioinformatics/18.1.207 20 TaoufikEPetitEDivouxDTsevelekiVMengozziMRobertsMLet alTNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury