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43 JelinekA.HeyderL.DaudeM.PlessnerM.KrippnerS.GrosseR.et al (2018)

We therefore investigated how the HCA-G PhIP-N2--D-glucuronide (PhIP-G), a representative liver metabolite of PhIP (2-Amino-1-methyl-6-phenylimidazo [4,5- b ] pyridine), which is the most abundant carcinogenic HCA in well-cooked meat, is transformed by enzymatic activity of human gut microbial representatives of the phyla Firmicutes , Bacteroidetes , and Proteobacteria

Interestingly, in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, a significant inverse association between plasma levels of betaine and colorectal cancer risk was observed only in participants with low folate concentrations [110] suggesting that choline and betaine may serve as alternative methyl group donors in states of folate deficiency

This effect appears to be mediated through stimulation of endothelial nitric oxide release leading to local vasodilatation (123,124)

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