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10.1186/s12906-017-1555-0 59

In further research, it was found that berberine achieved antioxidant effects by reducing the expression of pro-inflammatory factors, apoptotic factors and nuclear transcription factor B (NF-b), as well as up-regulating the expression of peroxlsome proliferator-activated receptor- coactlvator-1 (PGC-1) and manganese superoxide dismutase

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This approach reduces selective pressure for resistance development and has identified twelve virulence factors as potential drug targets, some of which are suitable for intracellular action or vaccine development (Liu et al., 2022)