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They begin with biology, hormones, stress cycles, and circadian rhythm disruption

In the acute stages after WM stroke, aged brains exhibit enlarged infarct volumes, severe WM damage, and greater oligodendrocyte death compared to younger brains (Rosenzweig and Carmichael, 2013)

This is how in certain circumstances, overexpression of HO, either HO-1 or HO-2 have been shown to exert prooxidant effects instead (Lamb et al., 1999

An excess of oxidants triggers oxidative stress (29), leading to a significant elevation in mitochondrial superoxide levels within ectopic endometrial tissue (30), which alters mitochondrial structure, particularly by expanding the surface area of the cristae