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We note that this enhancement did not fully restore efferocytosis to the level observed in M2 macrophages, suggesting that while the PKA-HSL axis is a critical component, other M2-specific factors also contribute to maximal efferocytosis function

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Additionally, if there is an imbalance in the gut microbiome, it can increase the number of lipopolysaccharides and interleukins, leading to skeletal muscle insulin resistance and psychiatric and neurodegenerative diseases [4]