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Furthermore, approximately half of the included trials were assessed as having a high or unclear risk of bias, which may compromise the overall reliability of the pooled results

The phosphorylation of histone H2AX was detected to evaluate the DNA damage related to behavioral activation therapy (BA) treatment, and CHE was further reported to increase the expression of gH2AX and regulate caspase-3 cleavage at different levels (Hammerov et al., 2011)