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These findings were further supported by the analysis of the trends with mAUC, which showed no statistically significant difference between groups (p fT3 = 0.147 and p fT4 = 0.132) (Supplementary Figures S3a and S4a)

Other possible mechanisms to improve insulin sensitivity in NAFLD reported in the literature include the regulation of the acetyl-CoA/CoA ratio in mitochondria, modulation of the pyruvate dehydrogenase complex (PDHC) activity, altering the expression of glycolytic and gluconeogenic enzymes as well as the expression of genes associated with the insulin signaling cascade, and stimulation of the insulin-like growth factor-1 (IGF-1) axis and IGF-1 signaling cascade (34, 55)

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Conversely, conditions that decrease the MCHC reduce disease severity

10.1016/j.freeradbiomed.2023.05.017 26 ElmoreS