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Pregnancy, uremia, iron deficiency, diabetes, and neuropathy are recognized as risk factors for the secondary variant of the disease.8 Nevertheless, the underlying pathophysiological mechanism of this disease remains incompletely.118 A study has shown that patients with RLS/WED have lower magnesium levels compared to healthy control groups.119 Several research investigations have similarly indicated that both oral and intravenous magnesium supplementation can be advantageous for these patients.9,16 Sinniah et al reported that a patient with RLS/WED made a full recovery after receiving an intravenous injection of magnesium sulfate.17,120 Additionally, another study suggests that oral magnesium supplementation may alleviate symptoms in individuals with moderate RLS.121 For patients with mild to moderate RLS or insomnia associated with periodic limb movements during sleep, magnesium could serve as a viable alternative therapeutic option.121 In the study of pregnant women, Yldrm found that the concentrations of zinc and magnesium in pregnant women afflicted with this disease were significantly lower compared to those observed in other women

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An increase in strength was demonstrated in older adults (mean age 65.2 years, range 6174 years) treated with HGH replacement therapy for 10 years at a mean initial dose of 0.72 mg/day, which was subsequently reduced to 0.37 mg/day