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- A brief review

281 Building on the previous finding that DSF inhibits aldehyde dehydrogenase (ALDH), preclinical studies have shown that the combination of DSF and Cu(II) selectively targets and kills ALDH + cancer stem cells, reducing the risk of tumor recurrence

A follow-up meta-analysis by Lewis and colleagues in the BMJ in 2005 confirmed this pattern the MTHFR genotypes effect on disease risk was greatest where folate intake was lowest and diminished where folate intake was adequate [6]

These are meaningful research paradigms

Bastaki M, Huen K, Manzanillo P, Chande N, Chen C, Balmes JR, Tager IB, Holland N