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Omeprazole is generally well tolerated, but long-term use is associated with potential risks including hypomagnesaemia (low magnesium), vitamin B12 deficiency, increased risk of Clostridioides difficile infection, and a modest increase in fracture risk as highlighted in MHRA Drug Safety Updates

Then the scale just stopped

Research Vial Dosing Phase III Equivalent Phase Day 1 onward Timing Every day Daily Dose 2 mg Notes No titration

It focuses on the following aspects

Intracranial efficacy and survival with tucatinib plus trastuzumab and capecitabine for previously treated HER2-positive breast cancer with brain metastases in the HER2CLIMB trial