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From an experimental study using a mouse model of immunologically induced fatigue, Vij et al

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Early indications suggest that administering Lactobacillus casei strain Shirota daily for two months may significantly lessen anxiety and restore eubiosis in ME/CFS patients [91]

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The resulting accumulation of extracellular glutamate may potentiate excitotoxicity, while astrocyte dysfunction compromises glutamine supply to neurons, ultimately disrupting the balance between excitatory and inhibitory signaling and contributing to cognitive and behavioral impairments