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Acknowledgements This work was supported by a project (HI21C0694, Development of treatment for intractable skin diseases using low-molecular compounds with enhanced Wnt/beta-catenin) funded by the Ministry of Health and Welfare, Republic of Korea and by the National Research Foundation of Korea(KRF) grant funded by the Korea government(MSIT) (RS-2025-16072747)

Nomenclature and rate equations

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IGF-I/BP-3 administration preserves hepatic homeostasis after thermal injury which is associated with increases in no and hepatic NF-kappa B