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MET activation is thus involved in brain plasticity, as suggested by the fact that HGF administration on hippocampal slices enhances the phosphorylation of the glutamatergic NMDA receptor subunit GluN1, augments the NMDA-mediated currents, and increases the amplitude of long-term potentiation (LTP) induced by elevated neuronal activity (Kato et al., 2012)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Ishimoto H, Wang Z, Rao Y, Wu C-F, and Kitamoto T (2013)

Other ALDHs, including ALDH1A1 and ALDH1B1, also contribute to acetaldehyde oxidation, albeit with lesser affinity than the ALDH2 isozyme (Wang et al., 2009