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Thus, different groups were or were not treated with GSH

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10.1007/s11357-024-01250-9 [DOI] [PMC free article] [PubMed] [Google Scholar] Luo X., Bai Y., He S., Sun S., Jiang X., Yang Z., et al

Although these classical inhibitors show great potential in preclinical research, their clinical translation still faces substantial obstacles, including poor metabolic stability, suboptimal pharmacokinetics, and the critical fact that no anti-ferroptosis drug has yet entered human trials

lower thermal stability TT individuals exhibit: Lower plasma folate Elevated plasma 5,10-methylene-THF Mild hyperhomocysteinemia Reduced global DNA methylation