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Additionally, Res alleviated PM2.5-induced lung inflammation and fibrosis by inhibiting autophagy and NLRP3 inflammasome activity, reducing IL-1 in BEAS-2B cells ( 3.2.4 Terpenoids Triptolide, a bioactive diterpene from Tripterygium wilfordii , was shown to downregulate mRNA and protein expression of -SMA, type I collagen, FN, and vimentin, inhibiting lung fibroblast migration and transformation

The term alkylene by itself or a part of another substituent refers to a straight or branched bivalent aliphatic hydrocarbon group derived from an alkyl group having from 1 to about 20 carbon atoms, e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 carbon atoms

Wu Y, Lin Z, Tang X, Tong Z, Ji Y, Xu Y, et al

IGF-1 is associated with muscle repair, cellular growth, and metabolic signaling

Candidates, such as SPR741 and pentamidine, are in clinical trials 12
