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Professional Liability for Physicians Separately from FDA legality, clinicians face licensing, malpractice, and professional risk if they use unapproved drugs outside appropriate research structures

Upon oral administration, gastrointestinal epithelium acts as a physical and biochemical barrier for absorption of proteins resulting in low bioavailability (typically less than 12%)

doi:10.1007/s00431-005-0033-8

Biomolecular surface coating to enhance orthopaedic tissue healing and integration