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A recent study further demonstrated that smoking increased the risk of ALD, cirrhosis, and HCC by 1.32-, 1.53-, and 1.53-fold, respectively (all p 1 pack/day), is associated with elevated alanine aminotransferase (ALT) levels in HCV antibody-positive patients [16]

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In contrast, the study of GSH-Pxs in prokaryotes remains underexplored, and they have been reported only in Streptococcus pyogenes , where a gsh-px mutant was associated to an impaired virulence in mice infection models [13]