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Studies have shown that environmental chemicals can disrupt the carefully orchestrated androgen-dependent processes essential for normal sperm development, from spermatogonial stem cell maintenance through final sperm maturation ( 4.1.2 Occupational exposure studies Workplace exposure investigations provide particularly valuable insights into EED toxicity due to higher exposure levels and better-controlled exposure assessment protocols

doi: 10.1074/jbc.M602164200

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It is also important to evaluate the magnitude of therapeutic effects of antioxidants on alterations in levels of a particular ROS at its presumptively proper action sites [138]