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The metabolomics data generated in the present study may be found in the MetaboLights repository under accession number MTBLS12389 or at the following URL: The RNA-sequencing data may be found in Gene Expression Omnibus database under accession number GSE294830 or at the following URL: The proteomics data may be found in the ProteomeXchange Consortium via PRIDE under accession number PXD063359 or at the following URL: www.ebi.ac.uk/pride/archive/projects/PXD063359

Leslie RD, Palmer J, Schloot NC, Lernmark A (2016) Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment

In fact, the thioldisulfide pool is thought to be primarily responsible for intracellular redox homeostasis and these reactions are important both for antioxidant defense and redox regulation of cell signaling (108)

Early pilot studies and case reports have shown feasibility and potential efficacy of various hydrogen delivery methods including inhaled gas, drinking hydrogen water, topical preparations, and hydrogen baths

This method may lead to more immediate and potent effects on increasing glutathione levels in the body