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Humanin has been shown to bind IGFBP3 in vitro and in vivo, interfering with IGFBP3induced apoptosis
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HPV positive HNSCC has shown more favorable prognosis than the HPV negative HNSCC which can also lessen the therapeutic dose of both radiation and chemotherapy in HPV positive disease treatment
References Angulo MC, Le Meur K, Kozlov AS et al (2008) GABA, a forgotten gliotransmitter
