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5 It also helps transport toxic compounds generated within the mitochondria out of the cell to prevent their accumulation

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Because of its membrane composition, the brain is particularly vulnerable to free radical insults that easily attack polyunsaturated fatty acids (PUFA), initiating lipid peroxidation reactions (see below)

doi: 10.1016/j.drudis.2020.11.002
In T-helper cells the PKM2-mediated activation of STAT3 promotes their differentiation and, as a result, the cell-mediated inflammatory processes of T-helper cells