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Metalloproteinase Regulation GHK-Cu exhibits sophisticated biphasic regulation of matrix metalloproteinases (MMPs) and their inhibitors

The specific mechanism is that L-theanine downregulates adrenocorticotropic hormone (ACTH) and corticosterone (CORT0), normalizes the excessive activity of the hypothalamic-pituitary-adrenal (HPA) axis, weakens the phosphorylation of NF-B in liver tissue, controls the inactivation of the NF-B signaling pathway, and thus inhibits an inflammatory state [71]