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These vitamins are also known as chain-breaking antioxidants [16]

Alternatively, the activation of receptor tyrosine kinase can inactivate GSK-3 via phosphorylation of upstream kinase Akt or extracellular signal regulated kinase (ERK), thereby allowing cytosolic -catenin to escape ubiquitin-dependent degradation [26]

However, successful implementation requires strategic planning, disciplined execution, and experienced regulatory writing expertise