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A stable derivative of vitamin C
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Phenytoin competes with valproate for binding to albumin, potentially increasing the free level of valproate
Early exploration of this type of linker was successfully conducted by Genentech/ImmunoGen, such as in the ADC drug trastuzumab emtansine (T-DM1 or Kadcyla) for treating HER2-positive metastatic breast cancer
