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A meta-analytic study of 24 studies with 9915 patients from diverse backgrounds identified that the PNPLA3 I148M variant was extensively associated with fibrosis (Fig

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This may lead to subsequent physiological abnormalities including gut dysbiosis and systemic inflammation, eventually resulting in a pathological clotting system, chronic endothelialitis, vasoconstriction, and hypoxia, as found in similar conditions such as heat stroke (183)

The size and quantity of the library were verified on the Agilent Bioanalyzer, and libraries were subjected to paired-end (2 100) sequencing on the Illumina HiSeq 4000 platform (Evrogen Joint Stock Company, Russia)