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without timely intervention, it may progress to the central visual field, potentially resulting in irreversible blindness (245)

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While combination therapies might improve effects, they can also increase the overall price levels

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encapsulated entacapone into PEGylated PLGA (PEG-PLGA@Ent) nanoparticles and nanostructured lipid carriers (NLCs) to enhance its bioavailability and pharmacological efficacy while mitigating its limitations, such as low oral bioavailability and rapid clearance 130
