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10.1101/2020.04.17.047704 155 HiltonJ

generated skeletal muscle-specific IGF-1R-null mice using the skeletal muscle actin promoter, which is active in differentiated muscle cells, and found that these mice did not show altered body weight or muscle mass [118] In the same study, ONeill et al

or (ii) offering any financial incentives or disincentives to persuade a patient to use a certain pharmacy

These alterations are thought to impact gut barrier integrity and immune function, both of which are implicated in CFS/ME pathophysiology

This phenomenon seems to be promoted by supplementation with high doses of vitamin B12 or its long-term use [106]