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Ridder IS, Rozeboom HJ, Kalk KH, Janssen DB, Dijkstra BW (1997) Three-dimensional structure of l-2-haloacid dehalogenase from Xanthobacter autotrophicus GJ10 complexed with the substrate-analogue formate

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Alternatively, peptide bond surrogates can have protease inhibitor activity at the substrate cleavage site, and therefore offer a fundamental strategy for understanding protease enzyme activity, especially if isosteres can imitate the transition state of bond degradation (hydrolysis)

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doi: 10.3390/molecules27082546 [DOI] [PMC free article] [PubMed] [Google Scholar] 48.Gopal S, Borovok I, Ofer A, et al
