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Additionally, when activated, the SAPK/JNK pathway can trigger the P53-YAP1 pathway, decrease GPX4 levels, promote ROS accumulation, and increase susceptibility to ferroptosis [134-136]

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A recent bibliometric review indicates that sulforaphane is the most cited natural product activator of Nrf2 signaling [42]

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Overview Designed as a practical, awareness-raising guide for the clinician Provides key information relevant to the diagnosis and management of each primary immunodeficiency (PID) Comprises a series of case-oriented problems drawn from typical patient scenarios Enables prompt recognition of PIDs, thereby helping to avoid delayed diagnosis and its consequences Includes supplementary material: sn.pub/extras Includes supplementary material: sn.pub/extras Access this book Tax calculation will be finalised at checkout Other ways to access About this book Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system

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