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An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation

The findings of some of the clinical trials in which lipoic acid administration has been tested in diabetic patients during the last 10 years are summarized

Recent studies in melanoma have identified a protein involved in iron flux at mitochondrialysosome contact sites, revealing that organelle-to-organelle iron compartmentalization plays a role in ferroptosis regulation
In addition, ROS modifies the intracellular influx of calcium, resulting in interstitial oedema, haemoconcentration, and ischemia, as well as further production of ROS, creating a self-perpetuating cycle [47]

Gaba induces A hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
