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A 500 um solution of Dihexa was prepared in acetonitrile and the collected liver microsomes were suspended in a solution of 0.5 mg/ml of 0.1 M Tris buffer at a pH 7.38

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The compounds discussed, including 5-Amino-1MQ, are not approved by the FDA for human or veterinary use

The results demonstrated that the infusion of GLP-1 during high level of glycemia significantly protects endothelial dysfunction and decreases hyperglycemia-induced oxidative stress see Table 2

These effects may translate into improved muscle recovery , reduced fatigue , and better performance , although human studies are still lacking and most data come from preclinical models (Ulanovskaya OA, 2013)