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The same group of the investigators developed DOX loaded HA-coated nanoparticles (DOX-HA-SPIONs) for imaging and drug delivery to cancer cells [14]

TBK1 phosphorylates IRF3 (interferon regulatory factor 3), which then dimerizes and translocates to the nucleus to induce transcription of type I interferons (IFN- and IFN-) and pro-inflammatory cytokines (Fig
10.1016/j.jtho.2016.10.014 J

And the number of cell in sphere shape in each group was shown in Figure 3F, which could be considered as a reflection of the severity of atrophy in PC12 cells

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