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Description
Further recent studies demonstrate that mtDNA not only acts as a ligand for cGAS to activate the STING pathway, but also exacerbates IFN-I-driven autoimmune inflammation through two additional mechanisms: metabolic-posttranslational modification regulation (e.g., lactylation modification enhances cGAS stability) and the formation of a positive feedback loop with cell death pathways (Zhang J
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[21] A comparison with antidepressants found that BPC-157 was effective in attenuating depression
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